Name | Regorafenib iMpurity |
Synonyms | Regorafenib iMpurity Regorafenib Impurity 30 Regorafenib Urea Impurity Regorafenib Monohydrate IMP Regorafenib Monohydrate Impurity AFP-CTF urea impurity (Regorafenib impurity) Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2-fluoro-4-hydroxyphenyl)- |
CAS | 1333390-56-9 |
Molecular Formula | C14H9ClF4N2O2 |
Molar Mass | 348.68 |
Density | 1.599±0.06 g/cm3(Predicted) |
Boling Point | 346.9±42.0 °C(Predicted) |
pKa | 9.21±0.31(Predicted) |
Storage Condition | 2-8°C |
Use | regorafenib impurity 1-(4-chloro-3-(trifluoromethyl) phenyl)-3-(3-fluoro-4-hydroxyphenyl) urea is an impurity that produces the structure shown below during the production of regorafenib. Regorafenib is a novel multi-kinase inhibitor developed by Bayer company, which can inhibit a variety of protein kinases to promote tumor growth, and target tumor formation, maintenance of tumor angiogenesis and tumor microenvironment signaling. |